Utopia Talk - Politics - Genetics, covid and neandertals

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Utopia Talk / Politics / Genetics, covid and neandertals

Nimatzo
rank Sun Jul 05 12:35:24 2020
This is a pre-print, so it has not been reviewed yet.

Abstract

A recent genetic association study (Ellinghaus et al. 2020) identified a gene cluster on chromosome 3 as a risk locus for respiratory failure in SARS-CoV-2. Recent data comprising 3,199 hospitalized COVID-19 patients and controls reproduce this and find that it is the major genetic risk factor for severe SARS-CoV-2 infection and hospitalization (COVID-19 Host Genetics Initiative). Here, we show that the risk is conferred by a genomic segment of ~50 kb that is inherited from Neandertals and occurs at a frequency of ~30% in south Asia and ~8% in Europe.

http://www.biorxiv.org/content/10.1101/2020.07.03.186296v1

Hrothgar
rank Sun Jul 05 21:54:05 2020
Interesting, but this seems flawed with reality where the largest deaths per 100k of population are coming from people with darker skin. Possible vitamin D deficiency situation. African and Latinos descendants don't have nearly as much neanderthal genetics as Asians/Europeans.

http://www.apmresearchlab.org/covid/deaths-by-race

Nimatzo
rank Sun Jul 05 22:31:15 2020
It’s not an either or thing. Groups can still die at higher rate from covid for other reasons. Like vitamim D, social patterns and other genetic factors.

Nimatzo
rank Sun Jul 05 22:33:31 2020
It’s about risks and the study claims to have identified a genetic risk factor. If true it would be wise that it be included in the calculation.

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Nimatzo rank	Sun Jul 05 12:35:24 2020 This is a pre-print, so it has not been reviewed yet. Abstract A recent genetic association study (Ellinghaus et al. 2020) identified a gene cluster on chromosome 3 as a risk locus for respiratory failure in SARS-CoV-2. Recent data comprising 3,199 hospitalized COVID-19 patients and controls reproduce this and find that it is the major genetic risk factor for severe SARS-CoV-2 infection and hospitalization (COVID-19 Host Genetics Initiative). Here, we show that the risk is conferred by a genomic segment of ~50 kb that is inherited from Neandertals and occurs at a frequency of ~30% in south Asia and ~8% in Europe. http://www.biorxiv.org/content/10.1101/2020.07.03.186296v1
Hrothgar rank	Sun Jul 05 21:54:05 2020 Interesting, but this seems flawed with reality where the largest deaths per 100k of population are coming from people with darker skin. Possible vitamin D deficiency situation. African and Latinos descendants don't have nearly as much neanderthal genetics as Asians/Europeans. http://www.apmresearchlab.org/covid/deaths-by-race
Nimatzo rank	Sun Jul 05 22:31:15 2020 It’s not an either or thing. Groups can still die at higher rate from covid for other reasons. Like vitamim D, social patterns and other genetic factors.
Nimatzo rank	Sun Jul 05 22:33:31 2020 It’s about risks and the study claims to have identified a genetic risk factor. If true it would be wise that it be included in the calculation.
	show deleted posts

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